Controversial Alzheimer’s Disease theory could pinpoint new drug targets


High levels of active misfolded proteins — the dead forms of which have long been targeted by researchers for gumming up the brain's signaling activity — may play a role in Alzheimer's disease, according to a study involving a Nobel Prize-winning UCSF scientist.

The discovery of so-called "prions" — which Dr. Stanley Prusiner of the University of California, San Francisco, dubbed the misfolded proteins more than three decades ago — potentially could focus researchers on new targets for the…

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